What are the downsides?
In the doses used for the treatment of depression, ketamine may cause temporary dissociation (feeling like things are not real, or that you are not in your body), sedation, impaired coordination and balance, nausea, and dizziness or vertigo. It may also cause a headache, increased heart rate, and increased blood pressure for a short time after each dose. All of these side effects usually resolve within an hour, if they happen at all. Ketamine is a potentially addictive substance and can (rarely) lead to craving, dependence, or abuse.